Our location in the heart of San Diego’s thriving life sciences community means our team is made up of industry-leading experts in a range of disciplines and from a variety of backgrounds, united by a shared passion for turning science into meaningful discoveries for cancer patients.
The power to stop cancer.
The experience to know how.
The dedication to make a difference.
Dual purpose enabling a targeted medicine approach
Part of a treatment strategy known as theragnostics, radiopharmaceuticals can be used for both therapy and diagnosis.
Radiopharmaceuticals, when tethering a radionuclide suitable for imaging, create a map of cancerous tumors in the body that provides precise diagnostic information. From the imaging results, the patients who are most likely to respond are identified and treated with individualized regiments of the therapeutic version of the same radiopharmaceutical. This precision medicine approach seeks to make substantial improvements in clinical outcomes.
Approach
Small molecules, tethered with powerful radioisotopes, are designed to exquisitely bind to receptors overexpressed in cancer and deliver powerful radiation to kill tumors, without affecting normal tissue.
Our unique approach marries a vast knowledge of GPCR biology with unrivaled proficiency in small molecule medicinal chemistry to develop potent and highly selective radiopharmaceuticals. We take a fit-for-purpose approach, pinpointing the precise target and selecting the ideal small molecule ligand paired with the optimal radioisotope to achieve a therapeutic effect.
Novel targets for solid tumors
Largest gene family in humans
132 known protein/receptor pairs
>65 with increased tumor expression
Given GPCR overexpression in many tumors, they can be targeted in a vast range of cancer indications, from common to rare tumors.
Clinical trials
Study R8760-101 is a multi-center Phase 1 clinical trial evaluating the safety and dosimetry of 68Ga-R8760, a first-in-class small molecule radioligand imaging agent being developed for patients diagnosed with adrenocortical carcinoma. 68Ga-R8760 was discovered by Radionetics Oncology for identifying melanocortin 2 receptor (MC2R)-expressing adrenocortical cancer lesions to select patients who may benefit from MC2R-directed radioconjugate therapy.
For additional information about the study, please see study NCT05999292
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Ana Kusnetzow, Ph.D.
Ana Kusnetzow, Ph.D., is a founding member of Radionetics and serves as Senior Vice President, Biology. Prior, she was a co-founder of Crinetics Pharmaceuticals Inc. and most recently served as Senior Director, Biology where she led the biology group that supported multiple discovery programs. She co-led the Crinetics discovery program that gave rise to the targeted radiotherapeutics platform that is the basis of the Radionetics pipeline. She was concurrently the program leader for a first-in-class ACTH antagonist, CRN04894, for the treatment of diseases caused by excess ACTH (e.g., Cushing’s disease and congenital adrenal hyperplasia). As a co-founder of Crinetics, she established diverse biology capabilities supporting small molecule and biologics drug development from the ground up, culminating in a $40 million Series A and subsequent financings leading to IPO in 2018, and was a significant contributor to the success of the discovery team that nominated several clinical candidates. Prior to this, Dr. Kusnetzow held a scientific position at Neurocrine Biosciences, Inc. Throughout her career, Dr. Kusnetzow has focused on the structural and pharmacologic characterization of G-protein-coupled receptors to aid in drug discovery and development. Dr. Kusnetzow holds a Ph.D. in Chemistry from Syracuse University, as well as a B.S. from Adrian College. She also conducted post-graduate training at the Jules Stein Eye Institute, Geffen School of Medicine at the University of California, Los Angeles.